비만, 염증반응, 인슐린저항의 관계(relation between obesity, inflammation, insulin resistance)
- 최초 등록일
- 2008.10.22
- 최종 저작일
- 2008.10
- 27페이지/
MS 파워포인트
- 가격 1,000원
소개글
최근 비만에대한 관심이 높아지면서, 비만이 염증반응, 인슐린전항성을 유도하게 된다는 논문이발표되었는데, 이논문의 내용을 리뷰형식으로 소개하고자 한다.
목차
Relationship between obesity, inflammation, and insulin resistance
introduction
Adipocyte
Adipokines related to Inflammation and Insulin resistanc
Leptin
TNF-α
Interleukin-6
Resistin
Adiponectin
본문내용
Introduction
Obesity is a condition in which excess body fat has accumulated.
BMI ≥ 30kg/m2.
Excessive body weight is associated with cardiovascular disease, type 2 diabetes, cancer, obstructive sleepapnea, non-alcoholic fatty liver disease, etc.
Adipocyte
White adipose tissue
- commonly known fat cell type.
- The fat cells store triglycerides and cholesteryl ester as ecessive energe source.
- and secrete restin, adiponectin, and leptin as a adipokine
Brown adipose tissue
- these cells have considerable cytoplasm with lipid droplets scattered throughout.
- the brown color comes from the large quantity of mitochondria.
According to a recent striking discovery, obesity is associated with a chronic inflammation.
And adipocytes have the capacity to synthesize and secrete several factors called adipokines.
Some of them appear to play an important role in obesity-associated insulin resistance and cardiovascular complications.
Obesity
Chronic flammation
Insulin resistance
In WAT(white adipose tissue) from obesity models, The expression of genes coding for proteins involved in inflammatory processes was markedly altered.
These variation in gene expression in WAT is related to macrophage infiltration in WAT.
Infiltrated macrophages produce TNF-α, IL-6, iNOS, etc.
So, increase in macrophage infiltration could induce inflammation.
Adipose tissue
Macrophage
Infiltration
참고 자료
Recent advances in the relationship between obesity, inflammation, and insulin resistance
