[발생학(생물)] Transcription Factors(전사인자)

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목차

1. Homeodomain (helix-turn-helix)
Hox
POU
LIM
Pax6

2. Basic helix-loop-helix (bHLH)

3. Basic leucine zipper (bZip)

4. Zinc finger
standard
Nuclear hormone receptors
Sry-Sox

본문내용

Homeodomain (helix-turn-helix)
One extremely important family of trans-regulatory factors is the set of homeodomain proteins. These proteins are critical for specifying the anterior-posterior body axes throughout the animal kingdom. The homeodomain consists of 60 amino acids arranged in a helix-turn-helix, such that the third helix extends into the major groove of the DNA that it recognizes. Amino acids in the amino-terminal portion of the homeodomain also contact the bases in the minor groove. This homeodomain was first seen in proteins that specify segment identity in Drosophila. Mutations of these proteins caused one body segment to be transformed into another (a transformation known as homeosis. Several of the homeodomain proteins of Drosophila melanogaster have been cloned, sequenced, and tested for their ability to regulate transcription. The recognition of specific promoters by homeodomain-containing proteins has been shown to be essential for Drosophila development.

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