A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer
- 최초 등록일
- 2014.03.25
- 최종 저작일
- 2012.08
- 12페이지/ MS 파워포인트
- 가격 1,500원
소개글
Biodegradable amphiphilic triblock copolymer의 합성방법 및 application
목차
1. Introduction
2. Synthesis
3. Synthetic method
4. Molecular design for special applications
5. Reference
본문내용
Aliphatic polyesters
PGA(poly(glycolic acid)), PLA(poly(lactic acid)), PCL(poly(ε-caprolactone)) and their copolymers
Important class of synthetic biodegradable polymers
Intrinsic properties : nonimmunogenicity, good biocompatibility, and biodegradability⇒ Widely used in biomedical applications
Limitation : Lack of pendant functional groups to which bioactive molecules can be covalently attached
PEG (poly(ethylene glycol))
Amphiphilic macromolecule
Useful properties : high solubility in both water and organic solvents, biocompatibility, ease in chemical modification
Widely used in chemical, biomedical, and industrial applications
참고 자료
A novel polymer – paclitaxel conjugate based on amphiphilic triblock copolymer, Zhigang Xie, Huili Guan, Xuesi Chen, Changhai Lu, Li Chen, Xiuli Hu, Quan Shi, Xiabin Jing, Journal of Controlled Release 117 (2007) 210–216
Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-Glutamic acid units, Huili Guan, Zhigang Xie, Peibiao Zhang, Chao Deng, Xuesi Chen, and Xiabin Jing, Biomacromolecules 2005, 6, 1954-1960
Macromolecular Anticancer Therapeutics, Springer New York, 221-263