LC MS/MS ionization (ESI & APCI)

목차

1. Basic aspects of electrospray ionization (ESI)
1.1. The taylor cone
1.2. Fate of sprayed droplets
1.3. Some further considerations

2. Atmospheric pressure chemical ionization (APCI)
2.1. Introduction
2.1.1. General features of chemical ionization
2.1.2. General features of atmospheric pressure chemical ionization
2.1.3. Historical background of APCI

2.2. Principles and apparatus
2.2.1. Corona discharge ionization mechanism
2.2.2. APCI main features and fields of applications

본문내용

2. Atmospheric pressure chemical ionization (APCI)
2.1.2. General features of APCI - The ionization mechanism of CI involves (acid-base reactions) - Requires efficient collisions among the reactant ions and the neutral analyte molecules present in the source - Atmospheric condition is more efficiency than vacuum condition - It can easily be interfaced with LC
2. Atmospheric pressure chemical ionization (APCI)
2.1.3. Historical background of APCI Horning(1973) - Illustrated the combination of APCI-MS with LC for the first time - Flow rates up to 1 or 2 ml/min → possible without any splitting
2. Atmospheric pressure chemical ionization (APCI)
2.1.3. Historical background of APCI Atmospheric pressure ionization (API) - APCI, ESI/ISI, APPI - Trace analysis in air Trace analysis gas analyzer (TAGA) MS Mobile MS which could provide real-time air analysis at trace levels

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