TGF 최종

소개글

TGF의 암 발생에 관해 어떤 역할을 하는지 자세히 나와있는 문헌입니다.

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Adenoviral overexpression of Smad3 augmented the upregulatory effect of TGF-β on MMP-13 expression by SCC cells.

Disruption of Smad signaling by adenoviral expression of kinase-defective TGF-β type I receptor, Smad 7, and dominant-negative Smad3 potently suppressed the basal and TGF-β-induced expression of MMP-13 and MMP-1 in SCC cells, and inhibited their basal and TGF-β-induced invasion through Matrigel and type I collagen.

Adenoviral over-expression of Smad7 in cutaneous and oral SCC cells significantly inhibited their implantation in skin of SCID mice and growth of xenografts in vivo, as compared to LacZ adenovirus-transduced control cells.

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