Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
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- 2011.11.26
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소개글
zebrafish의 생물학적인 의미에 대한 설명과
Zebrafish 심장재생이 심근세포의 역분화와 증식과 관련된다는 사실을 실험적으로 발혀낸 논문을 소개한 ppt 입니다.
목차
Background
What is Zebrafish?
Introduction
Result
Discussion
References
본문내용
Why Zebrafish?
Fully sequenced genome
Well-understood, easily observable and testable developmental behaviors
Rapid embryonic development (progressing from eggs to larvae in under three days)
Large, robust, and transparent embryos that develop outside the mother
Nearly constant size during early development facilitates simple staining techniques
Demonstrated similarity to mammalian models and humans in toxicity testing
Introduction
many non-mammalian vertebrate species are able to regenerate their hearts
Regenerated heart muscle cells are derived from the proliferation of differentiated cardiomyocytes
Proliferating cardiomyocytes undergo limited dedifferentiation
plk1 is an essential component of cardiomyocyte proliferation during heart regeneration.
Fig.1. Regenerated cardiomyocytes are derived from differentiated cardiomyocytes
참고 자료
Chris Jopling, Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation, Nature, 2010 March 25, pp. 606?609.
Angel Raya, Activation of Notch signaling pathway precedes heart regeneration in zebrafish, PNAS, September 30, 2003. pp. 11889-95
Jin-Ho Choi, Myocardial Regeneration: Present and Future, 한국지질동맥경화학회, 2004, pp. 331-339
http://en.wikipedia.org/wiki/Zebrafish