이식편 대 숙주질환

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간이나 신장 등 장기이식, 조혈모세포이식이나 골수이식 이후 생기는 이식편대 숙주질환, graft versus host disease (GVHD)에 대한 내용으로 의과대학생 수준으로 정리했습니다.
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본문내용

GVHD is the result of allogeneic T cells that
were either transferred with the donor`s stem cell
inoculum or develop from it, reacting with
antigenic targets on host cells
Definition
unrelated donors
advanced age
a female donor (particularly a multiparous donor)
cytomegalovirus seropositivity of the donor or patient
GVHD risk factors
Acute GvHD
occurs up to 100 days post BMT
Chronic GvHD
occurs post 100 days post BMT
Acute vsD
Acute GVHD
Pathology
Clinical manifestations (Skin)
Skin
1ST manifestation of GvHD
maculopapular rash
generalized erythroderma
desquamation
Distribution of rash on surfaces of limbs, face, neck, palms of hands and soles of feet
Acute GVHD Skin
Acute GVHD Hands
Liver
Jaundice
Raised liver enzymes
, AST/ALT )
Clinical manifestations (Liver)
Gut
Usually follows GvHD several weeks later
Diarrhea, Abdominal pain, and Nausea

참고 자료

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