Neurogenesis and neuronal migration of dopaminergic neurons during mesencephalon development in mice
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical and Translational Research / 19권 / 4호
ㆍ저자명 : Mun-ki Kim, Si-Joon Lee, Anju Vasudevan, Chungkil Won
ㆍ저자명 : Mun-ki Kim, Si-Joon Lee, Anju Vasudevan, Chungkil Won
목차
IntroductionMaterials and Methods
Animals
5-Bromodeoxyuridine labeling and immunohistochemistry
Results
Neurogenesis and neuronal migration in the mesencephalon
Dopaminergic neuronal development in the mesencephalon
Discussion
References
영어 초록
Dopaminergic neurons are one of the major neuronal components in the brain. Mesencephalon dopamine (DA) neurogenesis takes place in the ventricular zone of the floor plate, when DA progenitors divide to generate postmitotic cells. These cells migrate through the intermediate zone while they differentiate and become DA neurons on reaching the mantle zone. However, neurogenesis and neuronal migration on dopaminergic neurons remain largely unexplored in the mesencephalon development. This study presents neurogenesis and neuronal migration patterns of dopaminergic neurons during mesencephalic development of the mouse. Neurons from embryonic day (E) 10–14 were labelled by a single injection of 5-bromodeoxyuridine and immunohistochemistry was performed. The neurogenesis occurred mainly at the E10 and E11, which was uniformly distributed in the mesencephalic region, but neurons after E13 were observed only in the dorsal mesencephalon. At the postnatal day 0 (P0), E10 generated neurons were spread out uniformly in the whole mesencephalon whereas E11-originated neurons were clearly depleted in the red nucleus region. DA neurons mainly originated in the ventromedial mesencephalon at the early embryonic stage especially E10 to E11. DA neurons after E12 were only observed in the ventral mesencephalon. At E17, E10 labelled neurons were only observed in the substantia nigra (SN) region. Our study demonstrated that major neurogenesis occurred at E10 and E11. However, neuronal migration continued until neonatal period during mesencephalic development.참고 자료
없음"Journal of Biomedical and Translational Research"의 다른 논문
Successful remission with L-CHOP for primary mediastina..6페이지
Development and validation of LC-MS/MS for bioanalysis ..10페이지
Stage specific transcriptome analysis of liver tissue f..9페이지
Clinical characteristics and outcomes in patients with ..6페이지
Quality characteristics of improvement pellet nuruk ino..7페이지
Screening of immunoactive ingredients in frequently con..11페이지
Evaluation of effect over time after oral administratio..6페이지
Echocardiographic evaluation of heart failure in dogs w..7페이지
The effect of Puerariae Radix on ovariectomy-induced bo..6페이지
The immune enhancing effects and characteristics of Bif..8페이지