Effects of aluminum on the behavior and regeneration of planarian
(주)코리아스칼라
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- 2023.06.05
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- 2021.06
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서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical and Translational Research / 22권 / 2호
ㆍ저자명 : Yong-Jin Kim, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Young-Joo Yi, Sang-Myeong Lee
목차
Introduction
Materials and Methods
Animals
Preparation of Al solution
Measurement of motility and seizure-like behaviorpatterns
Transmission electron microscopy
Regeneration assay
Whole-mount immunohistochemistry
Statistical analysis
Results
Al induces decreased motility and seizure-like behaviorin planarians
Al delays the eye regeneration of planarians
Organelle morphology was changed in planariansexposed to Al
Discussion
References
영어 초록
Aluminum (Al) is one of the most widely applied metals in various industries. Anthropogenic activities of industrial waste result in increased accumulation of Al in natural water resources and aqueous organisms, leading to increased heavy metal pollution in the environment. This will ultimately associate with health risks to all living beings including humans. The present study addresses the possible toxic effects of Al on the motility and regeneration of planarians, using Dugesia japonica as the experimental animal model. Planarians were exposed to varying concentrations of Al (50–1,200 mg/L) for 1 hr, and subsequently evaluated for their motility, seizure-like behaviors, regeneration and alterations of the cell-organelles in their body. Results of the study exhibit that increasing Al concentrations lead to decreased motility and increased seizure-like behaviors, especially the c-type and head bob behaviors in planarians (p<0.05). The regeneration ability in the tail segments was reduced by increased Al concentrations, and the eyespot and optic nerves were more clearly observed in the control groups than planarians exposed to Al. Organelle analysis revealed morphological abnormalities in the mitochondria, golgi apparatus, endoplasmic reticulum, and cilia in the head region of planarians, as compared to the control groups. Taken together, our results indicate that exposure to Al alters the behavior of planarians and delays the regeneration of amputated body parts. Therefore, we suggest that Al exposure adversely can affect the lives of aquatic organisms, and induce toxicity such as cell abnormalities in animals.
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