Effects of cadmium on the behavior and regeneration of Dugesia japonica
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서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical and Translational Research / 22권 / 1호
ㆍ저자명 : Yong-Jin Kim, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Juneno So, Young-Joo Yi, Sang-Myeong Lee
ㆍ저자명 : Yong-Jin Kim, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Juneno So, Young-Joo Yi, Sang-Myeong Lee
목차
IntroductionMaterials and Methods
Experimental animals and reagents
Examination of motility and seizure-like behaviors
Observation of regeneration pattern
Whole-mount immunohistochemistry
Statistical analysis
Results
Aberrant motility was observed in planarian exposedto Cds
Eye formation of planarians in the presence of Cds
Discussion
References
영어 초록
This study was undertaken to evaluate the toxic effect of cadmium sulfate (Cds) on planarians (Dugesia japonica), and the suitability of planarians as an alternative animal model for toxicity studies. Planarians were exposed to varying concentrations of experimental solutions containing 0.1–25 mg/L Cds, and incubated for 1, 3, and 5 hrs. Motility, seizure-like behaviors (c-like, head-bop, snake-like, and screw-like) and regeneration ability of the amputated fragment were subsequently evaluated. Results showed decreased motility with increasing concentrations of Cds (p<0.05), with the lowest motility being observed at the highest concentration of 25 mg/L Cds. Results also indicate that seizure-like behavior patterns were significantly affected by increments in the Cds concentrations, especially the c-like and head-bop behaviors were notably increased. Compared to the control, the regeneration ability of the planarians was decreased in the experimental solutions containing Cds. Planarians exposed to Cds showed either delayed eye formation or no eye regeneration during incubation. Moreover, increased concentrations of Cds resulted in failure to regenerate and death of the planarians. In conclusion, this study confirm that the heavy metal Cds exerts a toxic effect on planarians. Furthermore, the performances of the planarians in the experimental period exhibit their suitability as an alternative animal model for toxicity studies.참고 자료
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