서브마이크론 입자 형태 커큐민의 생체 흡수율 및 제품 조성에 따른 흡수율 동등성 연구

서지정보

ㆍ발행기관 : 한국산업식품공학회 ㆍ수록지정보 : 산업식품공학 / 21권 / 3호
ㆍ저자명 : 박희정, TsukasaTakahashi, HitomiOzawa

영어 초록

Curcumin have various health-beneficial properties in numerous studies. However, its bioavailability is low due to its limited intestinal uptake and rapid metabolism. This study aimed to evaluate the pharmacokinetics of newly developed sub-micron particle curcumin with increased water dispersibility (Theracurmin CR-033P). Plasma curcumin levels were measured at 0, 1, 2, 4, 8 h after Theracurmin CR-033P intake using high-performance liquid chromatography. For analyzing pharmacokinetics of Theracurmin CR-033P, eighteen healthy subjects were recruited and received Theracurmin CR-033P at a single oral dose containing curcumin 30 mg. Cmax was 28.14 ng/ml, and the area under the curve for 8 h was estimated to be 104.36 ng/ml. Based on the area under the plasma concentration (AUC), the bioavailability of sub-micron particle curcumin was higher 22-, 35-, 28-fold than native curcumin in men, women, and all subjects, respectively. For comparing by formulation, seven healthy subjects were recruited and received two type of treatment: (1) existing dosage form 300 mg (contained curcumin 30 mg) 3 capsule, (2) high dosage form 300 mg (contained curcumin 90 mg) 1 capsule + placebo 300 mg 2 capsule. In the cross-over study, there was no significant differences in Cmax and AUC of plasma curcumin. In conclusion, submicron particle curcumin with increased water dispersibility significantly improved its oral bioavailability and women absorbed curcumin more effectively than men. Different formulation of Theracurmin CR-033P has shown equivalent to the reference in terms of pharmacokinetics.

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