Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells
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서지정보
ㆍ발행기관 : 대한구강생물학회
ㆍ수록지정보 : International Journal of Oral Biology / 45권 / 4호
ㆍ저자명 : Trang NTK, Hoon Yoo
ㆍ저자명 : Trang NTK, Hoon Yoo
목차
IntroductionMaterials and Methods
1. Materials and reagents
2. Cell culture
3. Cell viability assay
4. Western blotting
5. Immunofluorescence imaging
6. Statistical analysis
Results
1. Octyl gallate inhibited FaDu cell proliferation
2. OG’s effect on cell cycle regulators
3. OG induced caspase-dependent apoptosis
4. OG caused DNA damage on FaDu cells
5. OG suppressed the expression of integrin familyproteins
6. OG activated ERK and JNK in MAPK pathway
Discussion
Acknowledgements
Conflicts of Interest
References
영어 초록
The antitumor effects of octyl gallate (OG) were investigated on FaDu human hypopharyngeal squamous carcinoma cells. At various concentrations, OG inhibited the proliferation of FaDu cells by suppressing cell cycle regulators and induced apoptosis by activating caspase 3 and its downstream poly (ADP-ribose) polymerase, thereby damaging DNA. Immunoblotting demonstrated that OG significantly suppressed the expression of integrin family proteins (integrin α4, αv, β3, β4), hindering cell adhesion. The reduced expression of integrins subsequently mediated the mitogenactivated protein kinase signaling pathway to stimulate the activation of extracellular signal-regulated kinases and c-jun N-terminal kinases, leading to apoptosis. Thus, OG demonstrated antitumor activity on hypopharyngeal squamous carcinoma cells by suppressing cell proliferation and inducing apoptosis.참고 자료
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