The Immunoexpression of Visfatin in Oral Carcinogenesis from Korean Patients
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 39권 / 2호
ㆍ저자명 : Se-Ra Park, Hye-Yeon Han, Jiyeon Kim, Moon-Kyoung Bae, Mi Heon Ryu, Soo-Kyung Bae
ㆍ저자명 : Se-Ra Park, Hye-Yeon Han, Jiyeon Kim, Moon-Kyoung Bae, Mi Heon Ryu, Soo-Kyung Bae
목차
<AbstractⅠ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
1. Patients and tissue specimens
2. Immunohistochemical stain for visfatin
3. Evaluation of immunohistochemical stain
4. Statistical Analysis
Ⅲ. RESULTS
1. Immunohistochemical stain for visfatin
2. Correlation between visfatin and the clinicopathologicalparameters of OSCC patients
3. Correlation between visfatin and NF-kB p65 inOSCC patients
IV. DISCUSSION
V. REFERENCES
영어 초록
Visfatin is a pro-inflammatory cytokine, which is thought to play a central role in systemic inflammation and the pathogenesis of obesity related diseases. Only a few studies investigated the effect of visfatin on human cancers. Furthermore, there have been no studies on the association between the expression of visfatin in OSCC tissue and its effect on OSCC patients. Hence, the present study analyzed the expression of visfatin in OSCC from Korean patients. Immunohistochemistry for visfatin was performed using 12 normal oral mucosas (NOM), 16 oral leukoplakias (with/without dysplasia), and 58 OSCC patients samples. Immunoreactivity was semi-quantitatively scored and the correlation between the expression of visfatin and clinicopathological parameters of OSCC patients was analyzed. The immunohistochemical analysis demonstrated that the expression level of visfatin increased in OSCC alone (p<0.05). Moreover, the immunoexpression score of visfatin was significantly correlated with TNM stage of OSCC patients. Our findings suggested that visfatin can play a certain role in the pathogenesis of OSCC. In addition, visfatin was associated with the tumor progression of OSCC patients and may act as independent biomarker of OSCC.참고 자료
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