구강에 발생한 신경화 멜라닌세포성 모반의 면역조직화학적 특성:신경섬유종과의 비교

서지정보

ㆍ발행기관 : 대한구강악안면병리학회 ㆍ수록지정보 : 대한구강악안면병리학회지 / 37권 / 2호
ㆍ저자명 : 박현도, 조영아, 신의정, 홍성두, 이재일, 홍삼표, 윤혜정

목차

Ⅰ. Introduction
II. Material and Method
III. Results
1. Case history
2. Clinical findings
3. Histopathologic findings
4. Findings of immunohistochemical and specialstaining.
IV. Discussion
V. Conclusion
Ⅵ. References

영어 초록

Neurotized melanocytic nevus (NMN) is categorized into intradermal/intramucosal type of acquired melanocytic nevus. In contrast to typical intramucosal nevus which has relatively distinct histological features, the diagnosis of NMN requires more attention due to its mimicry of benign neural tumors such as neurofibroma. The majority of lesional cells, NMN cells, showed a spindle cell morphology and abundant, eosinophilic cytoplasm which were positive for S-100, vimentin, and collagen type IV. Positive reaction for MART-1 was detected in the NMN cells as well as in the epithelioid nevus cells beneath the epithelium. Neurofibroma exhibited diffuse positivity for S-100, vimentin, CD34 and collagen type IV, but never expressed MART-1. Toluidine blue stained the numerous mast cells scattered in the lesion of neurofibroma, compared to the relatively minor detection of mast cells in NMN. Therefore, MART-1 is a useful marker in differentiating NMN from neurofibroma.

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