사람 두경부세포암종에서 세포질 내 HuR 발현 및 미세혈관 밀도와 제 2형 사이클로옥시기나제 과발현과의 상관관계
(주)코리아스칼라
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- 2016.04.02
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 33권 / 6호
ㆍ저자명 : 한혜숙, 조성대, 심정현, 신지애, 조남표
목차
I. INTRODUCTION
II. MATERIALS AND METHODS
1. Patients and Tissue Collection
2. Immunohistochemistry
3. Scoring of the HuR and COX-2 stains
4. MVD quantification
5. Tatistical analysis
III. RESULTS
1. Clinicopathological data
2. Expression of HuR and COX-2 in HNSCC
3. Correlation between cytoplasmic HuRand COX-2 expression
4. Correlation between cytoplasmic HuR orCOX-2 expression and MVD
5. The relationship between clinicopathologic variables and the expression ofcytoplasmic HuR, COX-2, and MVD
IV. DISCUSSION
V. REFERENCES
영어 초록
The human embryonic-lethal abnormal vision-like protein, HuR, stabilizes mRNA containing adenine- and uridine- rich elements in their 3’untranslated region. Because cyclooxygenase-2 (COX-2) mRNA is a cellular transcript that contains an adenine- and uridine-rich element, it can be regulated by the HuR protein. In this study, we examined the relationship between COX-2, HuR, MVD, and the clinicopathological parameters. Nineteen out of 43 cases of HNSCC showed high level of COX-2expression, and 68% of these patients showed high COX-2 immuno-reactivity indicating the strong expression of the cytoplasmic HuR protein. Also, MVD expression in the cases with high COX-2 expression was higher than in the cases with low COX-2 expression. These results suggest a strong correlation between the overexpression of cytoplasmic HuR and COX-2 expression in HNSCC, and that COX-2 is associated with MVD in HNSCC. In conclusion, COX-2 regulated by cytoplasmic HuR may be a good tumor angiogenic factor in HNSCC.
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